Mad Science

EventAttack
??????
Pool
Event
Type
Attack
Cost
1 Energy
Target
One enemy

Cards that synergize with Mad Science

Feeding Frenzy
Skill
0
Gain 5 Strength this turn.
Feeding Frenzy gives Strength, and Mad Science adds it on every one of its hitsGain 5 Strength this turn.
Fight Me!
Attack
2
Deal 5 damage twice.
Gain 3 Strength.
The enemy gains 1 Strength.
Fight Me! gives Strength, and Mad Science adds it on every one of its hitsDeal 5 damage twice.
Gain 3 Strength.
The enemy gains 1 Strength.
Bulk Up
Power
2
Lose 1 Orb Slot.
Gain 2 Strength.
Gain 2 Dexterity.
Bulk Up gives Strength, and Mad Science adds it on every one of its hitsLose 1 Orb Slot.
Gain 2 Strength.
Gain 2 Dexterity.
Demon Form
Power
3
At the start of your turn, gain 2 Strength.
Demon Form gives Strength, and Mad Science adds it on every one of its hitsAt the start of your turn, gain 2 Strength.
Inflame
Power
1
Gain 2 Strength.
Inflame gives Strength, and Mad Science adds it on every one of its hitsGain 2 Strength.
Setup Strike
Attack
1
Deal 7 damage.
Gain 2 Strength this turn.
Setup Strike gives Strength, and Mad Science adds it on every one of its hitsDeal 7 damage.
Gain 2 Strength this turn.
Arsenal
Power
1
Whenever you create a card, gain 1 Strength.
Arsenal gives Strength, and Mad Science adds it on every one of its hitsWhenever you create a card, gain 1 Strength.
Brand
Skill
0
Lose 1 HP.
Exhaust 1 card.
Gain 1 Strength.
Brand gives Strength, and Mad Science adds it on every one of its hitsLose 1 HP.
Exhaust 1 card.
Gain 1 Strength.
Dominate
Skill
1
Apply 1 Vulnerable.
Gain 1 Strength for each Vulnerable on the enemy.
Exhaust.
Dominate gives Strength, and Mad Science adds it on every one of its hitsApply 1 Vulnerable.
Gain 1 Strength for each Vulnerable on the enemy.
Exhaust.
Monologue
Skill
0
Whenever you play a card this turn, gain 1 Strength this turn.
Monologue gives Strength, and Mad Science adds it on every one of its hitsWhenever you play a card this turn, gain 1 Strength this turn.
Prowess
Power
1
Gain 1 Strength.
Gain 1 Dexterity.
Prowess gives Strength, and Mad Science adds it on every one of its hitsGain 1 Strength.
Gain 1 Dexterity.
Resonance
Skill
1
3
Gain 1 Strength. ALL enemies lose 1 Strength.
Resonance gives Strength, and Mad Science adds it on every one of its hitsGain 1 Strength. ALL enemies lose 1 Strength.
Rupture
Power
1
Whenever you lose HP on your turn, gain 1 Strength.
Rupture gives Strength, and Mad Science adds it on every one of its hitsWhenever you lose HP on your turn, gain 1 Strength.

Relics that synergize with Mad Science

Red Skull
Red Skull gives Strength, and Mad Science adds it on every one of its hitsWhile your HP is at or below 50%, you have 3 additional Strength.
Brimstone
Brimstone gives Strength, and Mad Science adds it on every one of its hitsAt the start of your turn, gain 2 Strength and ALL enemies gain 1 Strength.
Ember Tea
Ember Tea gives Strength, and Mad Science adds it on every one of its hitsAt the start of the next 5 combats, gain 2 Strength.
Reptile Trinket
Reptile Trinket gives Strength, and Mad Science adds it on every one of its hitsWhenever you use a potion, gain 3 Strength this turn.
Shuriken
Shuriken gives Strength, and Mad Science adds it on every one of its hitsEvery time you play 3 Attacks in a single turn, gain 1 Strength.
Sword of Jade
Sword of Jade gives Strength, and Mad Science adds it on every one of its hitsStart each combat with 3 Strength.
Sling of Courage
Sling of Courage gives Strength, and Mad Science adds it on every one of its hitsStart each Elite combat with 2 Strength.
Girya
Girya gives Strength, and Mad Science adds it on every one of its hitsYou can now gain Strength at Rest Sites. (3 times max)
Mini Regent
Mini Regent gives Strength, and Mad Science adds it on every one of its hitsThe first time you spend each turn, gain 1 Strength.
Rainbow Ring
Rainbow Ring gives Strength, and Mad Science adds it on every one of its hitsThe first time you play an Attack, Skill, and Power each turn, gain 1 Strength and 1 Dexterity.
Sparkling Rouge
Sparkling Rouge gives Strength, and Mad Science adds it on every one of its hitsAt the start of your 3rd turn, gain 1 Strength and 1 Dexterity.
Toasty Mittens
Toasty Mittens gives Strength, and Mad Science adds it on every one of its hitsAt the start of your turn, Exhaust the top card of your Draw Pile and gain 1 Strength.
Vajra
Vajra gives Strength, and Mad Science adds it on every one of its hitsStart each combat with 1 Strength.

Rules and timing

Hidden from the in-game card library.

✦
Exterminate
Attack
1
Deal 3 damage to ALL enemies 4 times.
Peck
Attack
1
Deal 2 damage 3 times.
Rip and Tear
Attack
1
Deal 7 damage to a random enemy twice.
Maul
Attack
1
Deal 5 damage twice.
Increase the damage of ALL Maul cards by 1 this combat.
Hello World
Power
1
At the start of your turn, add a random Common card into your Hand.
Apotheosis
Skill
2
Innate.
Upgrade ALL your cards.
Exhaust.
Barrage
Attack
1
Deal 5 damage for each Channeled Orb.
Conflagration
Attack
1
Deal 2 damage to ALL enemies 4 times.

Changes by version

  1. 2 Jul 2026Bug fixVigorPlaytest
    Fixed an issue where Vigor was only applying to the first of Mad Science card's 3 hits when it was created with the Violence option
    Bug fixSupermassivePlaytest
    Fixed Supermassive card not scaling from cards generated by Mad Science card
  2. 18 Jun 2026Bug fixCrystal SphereJugglingStampedeHeadbuttv0.107.1
    Fixed state divergences related to event combats, the Crystal Sphere event, long event option resolution, Mad Science/Juggling cards with mixed combat speeds, and Stampede + Headbutt cards
  3. 7 May 2026Bug fixJugglingBeta branch
    Fixed state divergence related to Mad Science, Juggling, and mixed combat speeds
All 15 patch notes12 older
  1. 26 Mar 2026CostChaosTinker TimeBeta branch
    Mad Science Skill Chaos option (In the Tinker Time event) now uses Free to Play instead of Costs 0 Energy
  2. 19 Feb 2026Skill option108Internal playtest
    Skill option decreased from 10 to 8
  3. 9 Oct 2025Bug fixSoulInternal playtest
    Mad Science card no longer sets generated cards' star costs to 0 when the Soul option is chosen
  4. 2 Oct 2025Bug fixFocusEternalInternal playtest
    Mad Science card with Focus option can now randomly select Eternal cards to transform
  5. 14 Aug 2025CostInternal playtest
    Power option can no longer roll the cost 1 option
  6. 6 Feb 2025ChangeTinker TimeInternal playtest
    Changed Tinker Time event: Mad Science card default cost increased from 1 to 2; base damage and block values are changed accordingly
  7. 9 Jan 2025UpgradeInnateInternal playtest
    Changed Mad Science card; Now starts un-upgraded; upgrading it gives it Innate
    Bug fixInternal playtest
    Mad Science card no longer breaks when downgraded
  8. 7 Nov 2024Bug fixInternal playtest
    Mad Science transformation cards no longer stay on screen forever
  9. 3 Oct 2024Bug fixDiscoveryInternal playtest
    Discovery, Mad Science, and Stars in His Eyes cards can no longer generate healing cards
  10. 19 Apr 2024Bug fixInternal playtest
    Mad Science now properly displays hovertips for all of its effects
    ArtThe RegentInternal playtest
    New card art has been added for Mad Science, Loyalty, and many Regent cards
  11. 15 Sep 2023Bug fixInternal playtest
    Made Mad Science non-upgradeable instead of being upgraded when gained
  12. 1 Sep 2023Bug fixInternal playtest
    Mad Science can no longer be enchanted by Nimble when it's not a Skill

Internal playtest notes are from before the Early Access release. Names and numbers in them can differ from the game today.

Purchase today
If you haven't bought Slay The Spire 2 yet, it's time. Support the devs, they made an amazing game.Get it on Steam