Version

Envenom

SilentPowerRare
Whenever an Attack deals unblocked damage, apply 1 Poison.

Whenever one of your Attacks deals unblocked damage, that enemy gets 1 Poison. The check runs per damage instance, so a multi-hit Attack applies Poison for each hit that gets through, while a hit fully absorbed by Block applies nothing. Upgraded it applies 2 per hit. Poison ticks at the start of the enemy's turn and drops by 1 each turn.

Character
Type
Power
Rarity
Rare
Cost
2 Energy
Target
Yourself

When to take Envenom

Draft it once you have Shivs or multi hit attacks, typically by Act 2; it wants many small hits rather than one big one. In a long boss fight the Poison total outgrows most rares.

Cards that synergize with Envenom

Blade Dance
Skill
1
Add 3 Shivs into your Hand.
Exhaust.
Blade Dance and Infinite Blades supply cheap hits.Add 3 Shivs into your Hand.
Exhaust.
Infinite Blades
Power
1
At the start of your turn, add 1 Shiv into your Hand.
Blade Dance and Infinite Blades supply cheap hits.At the start of your turn, add 1 Shiv into your Hand.
Fan of Knives
Power
2
Shivs now hit ALL enemies.
Add 4 Shivs into your Hand.
Fan of Knives makes every Shiv poison the whole room.Shivs now hit ALL enemies.
Add 4 Shivs into your Hand.
Dagger Spray
Attack
1
Deal 4 damage to ALL enemies twice.
Dagger Spray and Skewer are multi-hit.Deal 4 damage to ALL enemies twice.
Skewer
Attack
X
Deal 8 damage X times.
Dagger Spray and Skewer are multi-hit.Deal 8 damage X times.
Accelerant
Power
1
Poison is triggered 1 additional time.
Accelerant ticks the Poison an extra time.Poison is triggered 1 additional time.
Bubble Bubble
Skill
1
If the enemy has Poison, apply 9 Poison.
Bubble Bubble builds on Poison, which Envenom appliesIf the enemy has Poison, apply 9 Poison.
Mirage
Skill
1
Gain Block equal to Poison on ALL enemies.
Exhaust.
Mirage builds on Poison, which Envenom appliesGain Block equal to Poison on ALL enemies.
Exhaust.
Outbreak
Power
1
Every 3 times you apply Poison, deal 11 damage to ALL enemies.
Outbreak builds on Poison, which Envenom appliesEvery 3 times you apply Poison, deal 11 damage to ALL enemies.

Relics that synergize with Envenom

Snecko Skull
Snecko Skull adds 1 Poison to each application.Whenever you apply Poison, apply an additional 1 Poison.
Permafrost
Permafrost triggers on Powers played, and Envenom is oneThe first time you play a Power each combat, gain 7 Block.
Lost Wisp
Lost Wisp triggers on Powers played, and Envenom is oneWhenever you play a Power, deal 8 damage to ALL enemies.
Mummified Hand
Mummified Hand triggers on Powers played, and Envenom is oneWhenever you play a Power, a random card in your Hand is free to play that turn.
Game Piece
Game Piece triggers on Powers played, and Envenom is oneWhenever you play a Power, draw 1 card.
Intimidating Helmet
Intimidating Helmet triggers on cards that cost 2 or more, and Envenom is oneWhenever you play a card that costs or more, gain 4 Block.

Changes by version

  1. 13 Nov 2025RarityUncommonRareInternal playtest
    Rarity changed from Uncommon to Rare
  2. 18 Sep 2025Cost12RarityRareUncommonInternal playtest
    Cost changed from 1 to 2 and rarity changed from Rare to Uncommon
  3. 15 May 2025Bug fixSnecko SkullInternal playtest
    Envenom card now properly triggers Snecko Skull relic
All 4 patch notes1 older
  1. 12 Jul 2024BuffInternal playtest
    Now costs 1 by default and deals 1 additional poison on upgrade

Internal playtest notes are from before the Early Access release. Names and numbers in them can differ from the game today.

Purchase today
If you haven't bought Slay The Spire 2 yet, it's time. Support the devs, they made an amazing game.Get it on Steam