Snakebite

SilentSkillCommon
Retain.
Apply 7 Poison.

It applies 7 Poison (10 upgraded) to one enemy. Poison makes the target lose HP equal to its stacks at the start of its turn, then drops by 1, so 7 Poison is 28 damage over seven turns and 10 Poison is 55. Retain means it stays in your hand across turns until you have the 2 Energy for it.

Character
Type
Skill
Rarity
Common
Cost
2 Energy
Target
One enemy
Unlock
Bigger PreyBeat Act 1 with the Silent

When to take Snakebite

The Common at the center of a Poison deck, and Retain lets you take it on turn one and cast it on a turn you do not need Block. The upgrade nearly doubles its total.

Cards that synergize with Snakebite

Bubble Bubble
Skill
1
If the enemy has Poison, apply 9 Poison.
Bubble Bubble adds 9 more once the enemy has Poison.If the enemy has Poison, apply 9 Poison.
Accelerant
Power
1
Poison is triggered 1 additional time.
Accelerant makes Poison tick an extra time.Poison is triggered 1 additional time.
Outbreak
Power
1
Every 3 times you apply Poison, deal 11 damage to ALL enemies.
Outbreak deals 11 to all every three applications.Every 3 times you apply Poison, deal 11 damage to ALL enemies.
Mirage
Skill
1
Gain Block equal to Poison on ALL enemies.
Exhaust.
Mirage turns the Poison into Block.Gain Block equal to Poison on ALL enemies.
Exhaust.

Relics that synergize with Snakebite

Snecko Skull
Snecko Skull adds 1 to every application.Whenever you apply Poison, apply an additional 1 Poison.
Intimidating Helmet
Intimidating Helmet triggers on cards that cost 2 or more, and Snakebite is oneWhenever you play a card that costs or more, gain 4 Block.

Changes by version

  1. 2 Oct 2025ReworkInternal playtest
    Reworked Snakebite card
  2. 6 Feb 2025Poison4(5)3(4)Internal playtest
    Poison decreased from 4 to 3 (upgraded 5 to 4)
  3. 16 Aug 2024Cost10Damage4(6)2(3)Poison6(7)4(5)Internal playtest
    Cost changed from 1 to 0, Damage decreased from 4 to 2 (upgraded 6 to 3) and Poison decreased from 6 to 4 (upgraded 7 to 5)
All 5 patch notes2 older
  1. 7 Jun 2024Upgraded Poison application78Internal playtest
    Upgraded Poison application increased from 7 to 8
  2. 5 May 2023ArtInternal playtest
    New card portrait for Snakebite

Internal playtest notes are from before the Early Access release. Names and numbers in them can differ from the game today.

Purchase today
If you haven't bought Slay The Spire 2 yet, it's time. Support the devs, they made an amazing game.Get it on Steam