Deadly Poison

SilentSkillCommon
Apply 5 Poison.

One energy applies 5 Poison to a single enemy (7 upgraded). Poison makes the enemy lose that much HP at the start of its turn and then drops by 1, so 5 Poison is 15 HP over five turns and 7 Poison is 28. The loss ignores Block, which is the whole appeal. It is a debuff, so Artifact stops it.

Character
Silent
Type
Skill
Rarity
Common
Cost
1 Energy
Target
One enemy

When to take Deadly Poison

Good early in Act 1 if you want a Poison plan, the cheapest way to stack a real Poison count. Take fewer copies once Noxious Fumes or Bouncing Flask are doing the work.

Cards that synergize with Deadly Poison

Bubble Bubble
Skill
1
If the enemy has Poison, apply 9 Poison.
Bubble Bubble needs Poison already present and then adds 9.If the enemy has Poison, apply 9 Poison.
Accelerant
Power
1
Poison is triggered 1 additional time.
Accelerant triggers Poison an extra time each turn.Poison is triggered 1 additional time.
Outbreak
Power
1
Every 3 times you apply Poison, deal 11 damage to ALL enemies.
Outbreak deals 11 to everyone every 3 applications.Every 3 times you apply Poison, deal 11 damage to ALL enemies.
Mirage
Skill
1
Gain Block equal to Poison on ALL enemies.
Exhaust.
Mirage turns the Poison you have spread into Block, and Burst plays it twice.Gain Block equal to Poison on ALL enemies.
Exhaust.
Burst
Skill
1
This turn, your next Skill is played an extra time.
Mirage turns the Poison you have spread into Block, and Burst plays it twice.This turn, your next Skill is played an extra time.

Relics that synergize with Deadly Poison

Snecko Skull
Snecko Skull adds 1 Poison to every application.Whenever you apply Poison, apply an additional 1 Poison.
✦
Corrosive Wave
Skill
1
Whenever you draw a card this turn, apply 2 Poison to ALL enemies.
Snakebite
Skill
2
Retain.
Apply 7 Poison.
Bouncing Flask
Skill
2
Apply 3 Poison to a random enemy 3 times.
Haze
Skill
3
Sly.
Apply 4 Poison to ALL enemies.
Poisoned Stab
Attack
1
Deal 6 damage.
Apply 3 Poison.
Noxious Fumes
Power
1
At the start of your turn, apply 2 Poison to ALL enemies.
Envenom
Power
2
Whenever an Attack deals unblocked damage, apply 1 Poison.
Bubble Bubble
Skill
1
If the enemy has Poison, apply 9 Poison.

Changes by version

  1. 22 Jan 2026ChangePoisonNeowHazeInternal playtest
    Changed Poison Neow Bundle: replaced Haze card to Deadly Poison
  2. 8 Jan 2026ArtInternal playtest
    Added Deadly Poison VFX
  3. 17 Oct 2024ArtInternal playtest
    Added green smoke puff VFX

Internal playtest notes are from before the Early Access release. Names and numbers in them can differ from the game today.

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