Pandora's Box

Pandora's Box

Ancient
Transform ALL Strikes and Defends.

On pickup, every basic Strike and Defend in your deck that can be removed is transformed at once, each into its own random card of any rarity, and a screen shows the results. Cards that cannot be removed are skipped, which includes Strikes made Eternal by Nutritious Soup. It fires once, so it cannot be traded in multiplayer.

Rarity
Ancient
Character
All characters

When to take Pandora's Box

Take it almost always in Act 1: it swaps eight or nine basics for real cards, an enormous jump in power. Later, once basics are gone, it does less and can even hurt a Strike deck.

Relics that synergize with Pandora's Box

Dolly's Mirror
Keep the hits with Dolly's Mirror and Pael's Growth, and clean up the misses with Empty Cage or Precise Scissors.Upon pickup, obtain an additional copy of a card in your Deck.
Pael's Growth
Keep the hits with Dolly's Mirror and Pael's Growth, and clean up the misses with Empty Cage or Precise Scissors.Upon pickup, Enchant a card with Clone.
Empty Cage
Keep the hits with Dolly's Mirror and Pael's Growth, and clean up the misses with Empty Cage or Precise Scissors.Upon pickup, remove 2 cards from your Deck.
Precise Scissors
Keep the hits with Dolly's Mirror and Pael's Growth, and clean up the misses with Empty Cage or Precise Scissors.Upon pickup, remove 1 card from your Deck.
New Leaf
New Leaf and Astrolabe are more of the same idea, and Bellows upgrades whatever the new hand is on turn 1.Upon pickup, Transform 1 card.
Astrolabe
New Leaf and Astrolabe are more of the same idea, and Bellows upgrades whatever the new hand is on turn 1.Upon pickup, Transform 3 cards, then Upgrade them.
Bellows
New Leaf and Astrolabe are more of the same idea, and Bellows upgrades whatever the new hand is on turn 1.The first Hand you draw each combat is Upgraded.

Changes by version

  1. 18 Jun 2026Bug fixNeowWishv0.107.1
    Fixed visual and navigation issues at Ancients: the next dialogue bubble peeking in early, navigating back to Neow's blessings from the Card Library, the card inspection button blocking the accept hotkey on Pandora's Box, and Wish card immediately selecting a grid card on the same controller press
  2. Fixed the card inspection button blocking the "accept" hotkey on the Pandora's Box card view screen
  3. 7 May 2026Bug fixBeta branch
    Fixed card inspection button blocking "accept" hotkey when looking at the Pandora's Box relic card view screen
All 8 patch notes5 older
  1. 2 Oct 2025InterfaceInternal playtest
    Pandora's Box relic now has an Accept button
  2. 12 Jun 2025TextInternal playtest
    Updated wording for Pandora's Box relic's info text in the card view screen
  3. 1 May 2025Bug fixInternal playtest
    Pandora's Box relic now flashes Egg relics over upgraded cards
  4. 9 Aug 2024Bug fixTezcataraInternal playtest
    Tezcatara's Ember enchantment no longer softlocks Pandora's Box relic
  5. Added StS1 relics: Bag of Preparation, Regal Pillow, Pandora's Box, Nunchaku

Internal playtest notes are from before the Early Access release. Names and numbers in them can differ from the game today.

Purchase today
If you haven't bought Slay The Spire 2 yet, it's time. Support the devs, they made an amazing game.Get it on Steam