Infection

Status
Unplayable.
At the end of your turn, if this is in your Hand, take 3 damage.
  • Source: you never draft this, enemies plant it.
  • Monsters: Phrog Parasite's Infect puts 3 copies into your Discard Pile, and Wriggler's Wriggle adds 1 while giving the Wriggler 2 Strength.
  • Unplayable: it is Unplayable, if it is still in your Hand at the end of your turn you take 3 damage.
  • Blockable: the code does not flag that damage unblockable, so Block you still hold at end of turn absorbs it, and it ignores Strength and Vulnerable.
  • Not Ethereal: it is not Ethereal, so it cycles back through your deck until the fight ends.
Type
Status
Cost
Unplayable

When to take Infection

Play around it by ending your turn with at least 3 Block per copy in hand, or by exhausting it first. Defect can turn it into fuel with Compact or ammunition with Flak Cannon.

Cards that synergize with Infection

Compact
Skill
1
Gain 6 Block.
Transform all Status cards in your Hand into Fuel.
Compact transforms it into Fuel.Gain 6 Block.
Transform all Status cards in your Hand into Fuel.
Flak Cannon
Attack
2
Exhaust ALL your Status cards.
Deal 8 damage to a random enemy for each card Exhausted.
Flak Cannon exhausts it for 8 damage.Exhaust ALL your Status cards.
Deal 8 damage to a random enemy for each card Exhausted.
Iteration
Power
1
The first time you draw a Status each turn, draw 2 cards.
Iteration draws 2 when it is the first Status you draw that turn.The first time you draw a Status each turn, draw 2 cards.
Purity
Skill
0
Retain.
Exhaust up to 3 cards in your Hand.
Exhaust.
Purity and Second Wind exhaust it before the damage lands.Retain.
Exhaust up to 3 cards in your Hand.
Exhaust.
Second Wind
Skill
1
Exhaust all non-Attack cards in your Hand. Gain 5 Block for each card Exhausted.
Purity and Second Wind exhaust it before the damage lands.Exhaust all non-Attack cards in your Hand. Gain 5 Block for each card Exhausted.

Changes by version

  1. 19 Mar 2026ArtBeta branch
    Infection affliction card overlay is no longer animated when Phobia Mode is turned
  2. 20 Feb 2025Bug fixInternal playtest
    Remote players' status cards that are played at end of turn (like Infection) come from their player rather than your hand
  3. 23 Jan 2025ArtInternal playtest
    Added portrait art
All 6 patch notes3 older
  1. 14 Nov 2024DamageInternal playtest
    Infection card damage increased from 1 to 3
    ChangeInternal playtest
    Infection cards given decreased from 4 to 3
  2. 26 Sep 2024BuffPhrog ParasiteInternal playtest
    Buffed Phrog Parasite: Infection cards given from Infest move increased from 3 to 4
  3. 16 Aug 2024ArtInternal playtest
    The Infection status is now covered with worms!

Internal playtest notes are from before the Early Access release. Names and numbers in them can differ from the game today.

Purchase today
If you haven't bought Slay The Spire 2 yet, it's time. Support the devs, they made an amazing game.Get it on Steam